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Differentiating Epileptic from Psychogenic Nonepileptic EEG Signals using Time Frequency and Information Theoretic Measures of Connectivity

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dc.contributor.author Barnes, Sarah
dc.date.accessioned 2021-11-25T07:38:53Z
dc.date.available 2021-11-25T07:38:53Z
dc.date.issued 2019
dc.identifier.uri ${sadil.baseUrl}/handle/123456789/585
dc.description 104 p. ; PDF (Masters Thesis) en_US
dc.description.abstract Differentiating psychogenic nonepileptic seizures from epileptic seizures is a difficult task that requires timely recording of psychogenic events using video electroencephalography (EEG). Interpretation of video EEG to distinguish epileptic features from signal artifacts is error prone and can lead to misdiagnosis of psychogenic seizures as epileptic seizures resulting in undue stress and ineffective treatment with antiepileptic drugs. In this study, an automated surface EEG analysis was implemented to investigate differences between patients classified as having psychogenic or epileptic seizures. Surface EEG signals were grouped corresponding to the anatomical lobes of the brain (frontal, parietal, temporal, and occipital) and central coronal plane of the skull. To determine if differences were present between psychogenic and epileptic groups, magnitude squared coherence (MSC) and cross approximate entropy (C-ApEn) were used as measures of neural connectivity. MSC was computed within each neural frequency band (delta: 0.5Hz-4Hz, theta: 4-8Hz, alpha: 8-13Hz, beta: 13-30Hz, and gamma: 30-100Hz) between all brain regions. C-ApEn was computed bidirectionally between all brain regions. Independent samples t-tests were used to compare groups. The statistical analysis revealed significant differences between psychogenic and epileptic groups for both connectivity measures with the psychogenic group showing higher average connectivity. Average MSC was found to be lower for the epileptic group between the frontal/central, parietal/central, and temporal/occipital regions in the delta band and between the temporal/occipital regions in the theta band. Average C-ApEn was found to be greater for the epileptic group between the frontal/parietal, parietal/frontal, parietal/occipital, and parietal/central region pairs. These results suggest that differences in neural connectivity exist between psychogenic and epileptic patient groups. en_US
dc.language.iso en en_US
dc.title Differentiating Epileptic from Psychogenic Nonepileptic EEG Signals using Time Frequency and Information Theoretic Measures of Connectivity en_US
dc.title.alternative A Thesis Submitted to the Graduate Faculty of GRAND VALLEY STATE UNIVERSITY In Partial Fulfillment of the Requirements For the Degree of Master of Science in Engineering, Biomedical Engineering Padnos College of Engineering and Computing en_US
dc.type Thesis en_US


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